Comparative Protein Structure Modeling Using MODELLER
نویسندگان
چکیده
منابع مشابه
Comparative Protein Structure Modeling Using Modeller Functional characterization of a protein sequence is one of the most frequent problems
Functional characterization of a protein sequence is one of the most frequent problems in biology. This task is usually facilitated by an accurate three-dimensional (3-D) structure of the studied protein. In the absence of an experimentally determined structure, comparative or homology modeling often provides a useful 3-D model for a protein that is related to at least one known protein structu...
متن کاملComparative modeling for protein structure prediction.
With the progression of structural genomics projects, comparative modeling remains an increasingly important method of choice. It helps to bridge the gap between the available sequence and structure information by providing reliable and accurate protein models. Comparative modeling based on more than 30% sequence identity is now approaching its natural template-based limits and further improvem...
متن کاملComparative Protein Structure Modeling in Genomics
The function of a protein is generally determined by its three-dimensional (3D) structure. Thus, it would be useful to know 3D structure of the thousands of protein sequences that are emerging from the many genome projects. This is the aim of structural genomics. The aim will be achieved by a focused, large-scale determination of protein structures by X-ray crystallography and nuclear magnetic ...
متن کاملM4T: a comparative protein structure modeling server
Multiple Mapping Method with Multiple Templates (M4T) (http://www.fiserlab.org/servers/m4t) is a fully automated comparative protein structure modeling server. The novelty of M4T resides in two of its major modules, Multiple Templates (MT) and Multiple Mapping Method (MMM). The MT module of M4T selects and optimally combines the sequences of multiple template structures through an iterative clu...
متن کاملModeller: generation and refinement of homology-based protein structure models.
and forces, holds promise for future refinements when applied wholesale, but is already capable of producing valuable insight when applied to structural detail. Calculation of macromolecular energy and forces with quantum mechanics requires considerably increased computational effort, and its possible use in refinement remains very much a topic for exploratory research. On the other hand, calcu...
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ژورنال
عنوان ژورنال: Current Protocols in Bioinformatics
سال: 2016
ISSN: 1934-3396,1934-340X
DOI: 10.1002/cpbi.3